Con preghiera di diffusione tra tutti i possibili interessati, scusandomi per invii multipli. Cordialmente, Giacomo Aletti
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Nell'ambito dei Reading Group Seminars e del Seminario di Matematica Applicata, in collaborazione col centro ADAMSS e il CIMAB, il giorno lunedì 13 Luglio 2015, alle ore 14.30, nell'Aula C del Dipartimento di Matematica dell'Universita' degli Studi di Milano, Via C. Saldini, 50, Milano,
"Not just theory: the role of computational neuroscience in clinical neurophysiology"
Pietro Balbi
Dept. of Neurorehabilitation 'Salvatore Maugeri' Foundation Scientific Institute of Pavia, IRCCS via Boezio 28
Abstract: Neurocomputational modelling has the ultimate goal of enhancing the understanding of the behavior of neural cells and circuits. This aim is usually reached by starting from the experimental phenomena, then by postulating hypotheses or conceptual models of the biophysical events, and finally by transforming them in computational models. The conversion of experimental data in neurocomputational models takes mainly advantage of two well established mathematical theories: the cable conductor theory and the Hodgkin-Huxley equations. In this seminar the considered experimental phenomena are represented by the axon-somatic back-propagation and the recurrent discharge, which are the basis of a clinical test known as the F wave. This is a neurophysiological test commonly used to assess the motor conduction along the most proximal segments of the peripheral axons. It results from the backfiring of antidromically activated spinal motoneurons. Until recently the test has been also used as a measure of motoneuronal excitability in experimental studies. By modelling the axon-somatic back-propagation and the recurrent discharge and by showing their dependance from the biophysical properties of the transition zone between axonal initial segment (AIS) and soma of the spinal motoneurons, a clearer insight is gained about the relations between the F wave and the spinal excitability. The modelling study appears able to provide both a clearer interpretation of the electrophysiological interplay between motoneuronal regions of high morphological inhomogeneity, and a novel demonstration of the flawed role of F-wave recordings in estimating the motoneuronal excitability.
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Per chi volesse seguire il seminario in remoto ricordo inoltre che sarà possibile avendo segnalato il proprio interessamento entro le 12 del giorno del seminario.
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Reading Group Seminars: The Reading Group Seminars (RGS) are organized within an open community of researchers interested in applying up to date mathematical modeling and data analysis approaches to the study of biological systems. The RGS take place at the Math. Department in Milan (via Saldini). Initiatives and updates are published on the website: http://rgs.mat.unimi.it/.(http://rgs.mat.unimi.it/)