Dear all, We are pleased to announce the first edition of the School *The Threads of Complex Networks — TCN2025* that will be held at Palazzo Strozzi in Florence (Italy) on September 16-19, 2025. The aim of the school is to present recent methodological, computational and machine learning methods for complex networks analysis, with applications spanning a wide range of fields. A Python tutorial will follow the lecture to show the implementation of the methods studied during the lectures. The school will start with the opening talk of *Prof. Rosario Mantegna *on September 16, 2025. The school provides minicourses delivered by five keynote speakers - *Tomaso Aste, *University College London, *From Filtered Information Structure to Causal Neural Design: Network-Theoretic Foundations for the Next Generation of Neural Models* - *Federico Battiston,* Central European University, *Higher-order Network Science* - *Ernesto Estrada*, Institute of Interdisciplinary Physics and Complex Systems (IFISC), *Diffusive Models on Networks* - *Giulio Rossetti*, Istituto di Scienza e Tecnologie dell’Informazione, National Research Council of Italy (ISTI-CNR), *Simulated Societies: from opinion dynamic modeling to AI-powered social digital twins* - *Andreia Sofia Teixeira*, Network Science Institute at Northeastern University London, *From Micro-Tensions to Macro-Patterns in Signed Social Systems and Mental Health* Detailed information on the School and instructions for application can be found at: https://tcn2025.wordpress.com/tcn2025/ The application deadline is *July 25, 2025.* The organizers, Roy Cerqueti Rosanna Grassi Fabrizio Lillo Giorgio Rizzini