Dear all,

it is our pleasure to invite you to a new talk of the One WorldABC Seminar.

Our next speaker will be Clara Grazian, who will talk about PET-ABC: A Bayesian likelihood free tool for kinetic models, on Thursday November 25, at 11.30am UK time, with an abstract reported below.

To join the talk, please click on the Zoom link below
https://chalmers.zoom.us/j/65793605413
Password: 810265

If you are interested in presenting your work on ABC and likelihood-free methods in the new year, please get in touch with one of the organisers.

If you miss last talk by Michael Gutmann, you can access its recording here

We look forward to seeing you on Thursday,
best wishes,
Massimiliano on the behalf of the One World ABC Seminar Organisers.
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When: Thursday, November 25, 11.30am UK Time
Speaker: Clara Grazian, UNSW Sidney 
Title: PET-ABC: A Bayesian likelihood free tool for kinetic models
Abstract: We describe an intuitive, easy to use method called PET-ABC that enables full Bayesian statistical inference from single subject dynamic PET data. The performance of PET-ABC was compared with weighted non-linear least squares (WNLS) in terms of reliability of kinetic parameter estimation and statistical power for model selection. Dynamic PET data based on 1-tissue and 2-tissue compartmental models were simulated with 2 noise models and 3 noise levels. PET-ABC was used to evaluate the reliability of parameter estimates under each condition. It was also used to perform model selection for a simulated noisy dataset composed of a mixture of 1- and 2-tissue compartment kinetics. Finally, PET-ABC was used to analyze a non-steady state dynamic study performed on a fully conscious rat administered either 2 mg.kg-1 amphetamine or saline 20 min after tracer injection.  

Reference:
Y. Fan, G. Emvalomenos, C. Grazian, S. R. Meikle, PET-ABC: fully Bayesian likelihood-free inference for kinetic models, Physics in Medicine and Biology, 66 (11), 115002, 2021. 



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Dr. Massimiliano Tamborrino
Assistant Professor
Department of Statistics
University of Warwick
https://warwick.ac.uk/tamborrino