Con preghiera di diffusione tra tutti i possibili interessati, scusandomi per invii multipli. Cordialmente, Giacomo Aletti

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Nell'ambito dei Reading Group Seminars e del Seminario di Matematica Applicata, il giorno lunedì 22 Settembre 2014, alle ore 14.30, nell'Aula C del Dipartimento di Matematica dell'Universita' degli Studi di Milano, Via C. Saldini, 50, Milano,

Silvia MAGGI, IIT Genova

terra' una conferenza dal titolo

Integrative Analysis of Electrophysiological and Behavioral Data in the After-hour Circadian Mouse Model

Abstract:

Physiological and behavioural changes can occur across different timescales. Circadian rhythms include a series of oscillations with approximately 24 hours periodicity and influence different functions in different domains. We have investigated the sleep-wake cycle and cognitive timing in the After-hours (Afh) mice, which carry a single point mutation in the Fbxl3 gene resulting in a substantial lengthening of the circadian period. The analysis of electroencephalogram (EEG) and electromyogram (EMG) signals, recorded under light-dark (LD) and dark-dark (DD) schedule revealed several differences in the sleep structure and sleep homeostasis between mutants and wild-type mice. Then, we investigated whether the alteration of circadian clock and sleep affected the estimation of short intervals and timing uncertainty in decision-making behavioral tasks over 24 hours. Differences in the daily distribution of sleep between Afh mutants and controls correlate with a reduced performance in mutants, suggesting that the mutation augments the effects of sleep inertia. A Generalized Linear model of our data provided a prediction of how the circadian clock and sleep affect behavioral/cognitive measures, uncovering novel dynamics between these two processes.

Reading Group Seminars:

The Reading Group Seminars (RGS) are organized within an open community of researchers interested in applying mathematical approaches to the study of biological systems. Updates on our initiatives can be found at: https://sites.google.com/site/readinggroupseminar as well as by subscribing to our RGS group https://groups.google.com/forum/#!forum/neurocomp-rgs