Good morning, I apologize for the short notice. Below is an announcement for an online seminar for the Deal.II-X project* (of which some of us are members) for this afternoon (May 5th) at 2:00 PM. The topic might be of interest. Best regards, Fabio * https://www.dealii-x.eu/ -------- Messaggio Inoltrato -------- Oggetto: Reminder: dealii-X Seminar Tuesday at 14:00 Data: Mon, 4 May 2026 21:09:46 +0200 Mittente: 'Ivan Prusak' via dealiix project <dealiix-project@vph-institute.org> Rispondi-a: Ivan Prusak <ivan.prusak@rub.de> A: dealiix-project@vph-institute.org <dealiix-project@vph-institute.org> CC: Alberto Salvadori <alberto.salvadori@unibs.it>, Mattia Serpelloni <mattia.serpelloni@unibs.it> Dear Colleagues, this is a kind reminder about the dealii-X seminar *tomorrow, May 5 *at*14:00. *The speakers are Alberto Salvadori and Mattia Serpelloni from UNIBS. Please find below the title and the abstract. The usual dealii-X meeting link: https://ruhr-uni-bochum.zoom-x.de/j/67234625691?pwd=tNlXdhaQVGakRuQ7ScR5mXYl... Best regards, Ivan *Title*: "Cellular Motility and Integrins Relocation: From Theory to HPC Simulations" *Abstract*: Numerous biological processes rely on cell motility and mechanosensing. These functions emerge from the coordinated interplay of multiple mechanotransductive mechanisms, in which the actin cytoskeleton and cell-matrix adhesions play a central role. During migration, actin polymerization at the leading edge drives protrusion against the resistance of the plasma membrane, generating forces that propagate through the lamellipodium and are ultimately transmitted to the extracellular matrix (ECM) via adhesion protein complexes. Those are mainly made of integrins, transmembrane adhesion receptors that are laterally mobile within the lipid bilayer. The membrane diffusion and active relocation enable integrins to sample the substrate, cluster upon ligand binding, and nucleate nascent focal adhesions at the leading edge. As retrograde actin flow engages integrins via talin and kindlin, mobile receptors are captured and stabilized, converting transient encounters into adhesive complexes. This coupling between integrin mobility and force transmission underlies the transition from short-lived nascent adhesions to more stable focal adhesions, while unengaged integrins continue to redistribute, sustaining adhesion turnover and directional cell migration. In this talk, we will present a continuum multiphysics theory for the engine, the adhesion, the relocation of integrins during cell locomotion. HPC simulations carried out in the dealii-X project of integrin redistribution during membrane advection are compared with experimental evidence. To unsubscribe from this group and stop receiving emails from it, send an email to dealiix-project+unsubscribe@vph-institute.org.