Cari colleghi,

Ho il piacere di segnalare il seguente seminario organizzato dal Dipartimento MEMOTEF, Università degli Studi di Roma La Sapienza.

*Data:* Venerdì 14 Giugno, ore 16.00-17.00 *Relatore: *Prof. William Fisher Rosenberger, Distinguished Professor in Mathematical Statistics @ George Mason University, USA *Titolo:* *Casual** Inference for Clinical *Trails**: A Spellchecker’s Guide to Randomization Tests in Complex Settings *Abstract:* Sir Austin Bradford Hill, the developer of the first randomized clinical trial, was a proponent of simplicity in statistical analysis, and strongly emphasized careful study design as the critical component of all medical studies. While he didn’t mention randomization tests in his 1937 book, I believe he would have liked their simplicity and interpretability. Any inference procedure which assumes random sampling from a population ignores Fisherian principles regarding the analysis of designed experiments. And clinical trials are the quintessential designed experiment. While we hear quite often about preservation of type I error rates and, more recently, about causal inference, these are natural elements of a randomization test. We discuss these issues and demonstrate that randomization tests can be used for more complex settings, such as multiple (>2) treatment comparisons, analyses with missing outcome data, and subgroup analyses. It is interesting to note that the only cohort of statisticians NOT excited about randomization tests in this age of causal inference are the designers and conductors of randomized clinical trials! I will conclude with a few historical notes about Fisher and de Finetti.

*The two most often misspelled words during speaker's term as Biometrics co-editor

Il seminario si terrà in *Aula 1 - GINI, Edificio di Scienze Statistiche*, piano terra, CU002, Città Universitaria, e potrà essere altresì seguito online via Zoom.

https://uniroma1.zoom.us/j/82089465970 Meeting ID: 820 8946 5970 -- Passcode: 140624Bill

Saluti, N

*Nina Deliu* Assistant Professor (RTDA) in Statistics – *MEMOTEF, Sapienza Università di Roma* Research Visitor* – Biostatistics Unit, University of Cambridge* Personal website: *https://nina-dl.github.io/ https://nina-dl.github.io/* X (Twitter): @DeliuNina

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