Colloqui della Classe di Scienze - Anno Accademico 2020/2021
Mercoledì 3 novembre 2021
ore 15:00
* Reidun Twarock *
(University of York, UK)
terrà un seminario dal titolo
* “ Mathematical Virology: A Novel Perspective on Virus Structure, Assembly
and Disassembly with Applications in Virus Nanotechnology”*
*abstract:*
Viral protein containers, called capsids, are repurposed for applications
in virus nanotechnology, including gene therapy and vaccinology. These
containers sit on a physico-chemical knife’s edge: they must be
sufficiently stable to provide protection for their cargoes, whilst
facilitating their timely release in the viral life cycle upon cues from
the host cell environment. In this talk, I will demonstrate that this
delicate balance hinges on geometric properties of the capsid, that we
classified via a generalised principle of quasi-equivalence. This theory
contains the seminal Caspar Klug theory of virus architecture as a special
case and provides geometric models for distinct capsid layouts in terms of
Archimedean lattices. Based on these results, we demonstrated that a
capsid’s propensity to fragment, a proxy for its ease of disassembly and
genome release, depends on two geometric/topological descriptors: its
surface lattice type, and the interaction network between its tiles. Tiling
models of viral capsids, and Hamiltonian paths associated with these
geometric descriptors also provide a better understanding of virus
assembly. This has been instrumental in the discovery of genome-encoded
virus assembly instructions and has provided a means to better understand
how this assembly mechanism works. We recently demonstrated that this
mechanism also spontaneously evolved in a bacterial system that packages
its own messenger RNA, resulting in increased packaging efficiency of the
nucleic acid into its protein container. This highlights the wider
importance of this assembly mechanism in biology and opens novel avenues
for applications in virus nanotechnology and therapy
*Classe di Scienze*
*Il seminario si terrà in modalità telematica. *
* Il link per collegarsi all'evento: Entra nella riunione in Zoom
https://us02web.zoom.us/j/85180677828?pwd=R2pwODYzYmdoSEpmcE50TVVnTzU1Zz09
<https://us02web.zoom.us/j/85180677828?pwd=R2pwODYzYmdoSEpmcE50TVVnTzU1Zz09>*
Valeria Giuliani
Scuola Normale Superiore
Servizio Attività Didattiche
tel. 050 509260
Piazza dei Cavalieri, 7
56126 Pisa
E-mail: valeria.giuliani(a)sns.it
E-mail: classi(a)sns.it
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*Avviso Seminari di Matematica*
Mercoledì 3 novembre 2021
>
>>
> ore 11:30
>>
> (Aula Volterra)
>
>> Scuola Normale Superiore
>>
>> Pisa
>>
>>
>> *Massimiliano Berti*
>> (SISSA-Trieste)
>>
>> terrà un seminario dal titolo:
*"Benjamin-Feir instability of Stokes waves in deep water"*
*abstract:*
Small-amplitude, traveling, space periodic solutions -- called Stokes waves
-- of the 2 dimensional gravity water waves equations in deep water are
linearly unstable with respect to long-wave perturbations, as predicted by
Benjamin and Feir in 1967. We completely describe the behavior of the four
eigenvalues close to zero of the linearized equations at the Stokes wave,
as the Floquet exponent is turned on. We prove in particular the conjecture
that a pair of non-purely imaginary eigenvalues depicts a closed figure
eight, parameterized by the Floquet exponent, in full agreement with
numerical simulations. Joint wotk with A. Maspero and P. Ventura.
il seminario si terrà in modalità mista.
Tutti gli interessati a partecipare in presenza devono contattare per email
il prof. Andrea Malchiodi (andrea.malchiodi(a)sns.it).
Per collegarsi da remoto il link :
https://teams.microsoft.com/l/meetup-join/19%3aU6a57NlVFWbcy9kcfM4uzZIySQNc…
Classe di Scienze
Valeria Giuliani
Scuola Normale Superiore
Servizio Attività Didattiche
tel. 050 509260
Piazza dei Cavalieri, 7
56126 Pisa
E-mail: valeria.giuliani(a)sns.it
E-mail: classi(a)sns.it
--
Hai ricevuto questo messaggio perché sei iscritto al gruppo "Matematici.Esterni.SNS" di Google Gruppi.
Per annullare l'iscrizione a questo gruppo e non ricevere più le sue email, invia un'email a matematici.esterni.sns+unsubscribe(a)sns.it.
Per visualizzare questa discussione sul Web, visita https://groups.google.com/a/sns.it/d/msgid/matematici.esterni.sns/CAGKKDB%3….